In vivo cardiac phase response curve elucidates human respiratory heart rate variability.
نویسندگان
چکیده
Recovering interaction of endogenous rhythms from observations is challenging, especially if a mathematical model explaining the behaviour of the system is unknown. The decisive information for successful reconstruction of the dynamics is the sensitivity of an oscillator to external influences, which is quantified by its phase response curve. Here we present a technique that allows the extraction of the phase response curve from a non-invasive observation of a system consisting of two interacting oscillators--in this case heartbeat and respiration--in its natural environment and under free-running conditions. We use this method to obtain the phase-coupling functions describing cardiorespiratory interactions and the phase response curve of 17 healthy humans. We show for the first time the phase at which the cardiac beat is susceptible to respiratory drive and extract the respiratory-related component of heart rate variability. This non-invasive method for the determination of phase response curves of coupled oscillators may find application in many scientific disciplines.
منابع مشابه
Modelling Heart Rate Variability Due to Respiration and Baroreeex
This chapter is devoted to the interactions of heart beat, respiration, and blood pressure oscillations. A nonlinear model is derived which describes the essential parts of the baroreceptor loop: blood pressure wave, baroreceptor activity, cardio-respiratory center, and regulation of heart rate and vascular resistance via the autonomic nerves. Special attention is devoted to the phase response ...
متن کاملComparison of the effect of aerobic exercise in water with two different temperatures with outside water environment on the index of very low frequency waves of heart rate variability in active young men
Introduction and purpose: Cardiac response to body core temperature variation measured with the very low-frequency parameter of heart rate variability. The aim of this study was to investigate the variability of very low frequency due to different temperatures of aerobic training in water and dry. Materials and methods: 40 academic active male were selected as research subjects. Then, all subje...
متن کاملEffect of endotoxemia on heart rate dynamics in rat isolated perfused hearts
Introduction: Beat-to-beat variation in heart rate shows a complex dynamics, and this complexity is changed during systemic inflammatory response syndrome (e.g. sepsis). It is not known whether or not cardiac pacemaker dynamical rhythm is affected by sepsis. The aim of this study was to investigate heart rate dynamics of isolated heart as well as expression of pacemaker channels (HCN) in a r...
متن کاملNon-invasive prediction of fluid responsiveness in infants using pleth variability index.
This prospective study assessed whether respiratory variations in velocity time integral, peak blood flow velocity and non-invasive pleth variability index are useful measurements in infants undergoing congenital heart surgery and determined threshold values that may help guide fluid administration. In 27 infants receiving mechanical ventilation, of mean (SD) weight 10.4 (6.3) kg, 13 increased ...
متن کاملEvaluation of the effects of aerobic exercise in the aqueous environment on heart rate variability by using Poincare plot nonlinear method
Background and Aim: Heart rate variability used as a non-invasive method to investigate the effect of aerobics exercise on the cardiac autonomic system. The aim of this study was the nonlinear analysis of the effect of aerobic exercise in the water on the cardiac autonomic system in academic youngchr('39')s males. Materials and Methods: A total of 28 young men were purposefully selected and ra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Nature communications
دوره 4 شماره
صفحات -
تاریخ انتشار 2013